Publications

Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity. Cui L, Chen SY, Lerbs T, Lee JW, Domizi P, Gordon S, Kim YH, Nolan G, Betancur P, Wernig G. Nat Commun. 2020 Jun 3;11(1):2795. doi: 10.1038/s41467-020-16466-4.PMID: 32493933 Free PMC article.

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer. Betancur PA, Abraham BJ, Yiu YY, Willingham SB, Khameneh F, Zarnegar M, Kuo AH, McKenna K, Kojima Y, Leeper NJ, Ho P, Gip P, Swigut T, Sherwood RI, Clarke MF, Somlo G, Young RA, Weissman IL. Nat Commun. 2017 Apr 5;8:14802. doi: 10.1038/ncomms14802.PMID: 28378740 Free PMC article.

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P, Maegdefessel L, Matic LP, Hedin U, Weissman IL, Leeper NJ. Nature. 2016 Aug 4;536(7614):86-90. doi: 10.1038/nature18935. Epub 2016 Jul 20.PMID: 27437576 Free PMC article.

Expression and function of transcription factor cMyb during cranial neural crest development. Betancur P, Simões-Costa M, Sauka-Spengler T, Bronner ME. Mech Dev. 2014 May;132:38-43. doi: 10.1016/j.mod.2014.01.005. Epub 2014 Feb 6.PMID: 24509349 Free PMC article.

Assembling neural crest regulatory circuits into a gene regulatory network. Betancur P, Bronner-Fraser M, Sauka-Spengler T. Annu Rev Cell Dev Biol. 2010;26:581-603. doi:10.1146/annurev.cellbio.042308.113245.PMID: 19575671 Free PMC article. 

A Sox10 enhancer element common to the otic placode and neural crest is activated by tissue-specific paralogs. Betancur P, Sauka-Spengler T, Bronner M. Development. 2011 Sep;138(17):3689-98. doi: 10.1242/dev.057836. Epub 2011 Jul 20.PMID: 21775416 Free PMC article.

Genomic code for Sox10 activation reveals a key regulatory enhancer for cranial neural crest. Betancur P, Bronner-Fraser M, Sauka-Spengler T.Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3570-5. doi: 10.1073/pnas.0906596107. Epub 2010 Feb 5.PMID: 20139305 Free PMC article.

Miniature neurotransmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis. Sutton MA, Ito HT, Cressy P, Kempf C, Woo JC, Schuman EM. Cell. 2006 May 19;125(4):785-99. doi: 10.1016/j.cell.2006.03.040.PMID: 16713568 Free article.

Corneal keratocytes retain neural crest progenitor cell properties. Lwigale PY, Cressy PA, Bronner-Fraser M. Dev Biol. 2005 Dec 1;288(1):284-93. doi:10.1016/j.ydbio.2005.09.046. Epub 2005 Nov 2.PMID: 16263107 Free article.